The active ingredient of Kamagra polo, sildenafil, inhibits phosphodiesterase type 5 (PDE5). It inhibits the PDE5 enzyme, which degrades cyclic guanosine monophosphate (cGMP) levels, a substance that helps blood arteries dilate and smooth muscle tissues relax.

Penis blood vessel relaxation is brought on by PDE5 suppression. It aids a guy in keeping a powerful erection throughout sex. It also relaxes the muscles of the bladder and prostate to reduce frequent urination in BPH and dilates pulmonary blood veins to treat PAH.